| 丙二醛溶血作用的机制 |
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| 引用本文： | 尹长城,潘华珍.丙二醛溶血作用的机制[J].中国生物化学与分子生物学报,1987,3(3):207-211. |
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| 作者姓名： | 尹长城 潘华珍 |
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| 作者单位： | 中国医学科学院基础医学研究所 北京
(尹长城)，中国医学科学院基础医学研究所 北京(潘华珍) |
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| 摘 要： | 脂质过氧化产物丙二醛可引起溶血。本文用丙二醛处理红细胞,发现膜磷脂可与丙二醛交联形成荧光化合物;丙二醛又可使血红蛋白变性,产生一个棕色物质,经质谱及光谱特征鉴定为高铁卟啉,此物质可使红细胞破溶。
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| 关 键 词： | 脂质过氧化 丙二醛 磷脂 溶血 |
| 收稿时间： | 1987-06-20 |
THE EFFECT AND MECHANISM OF MALONYLDIALDEHYDE ON ERYTHROCYTESA HEMOLYSIS |
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| Yin,Chang-cheng Pan,Hua-zhen.THE EFFECT AND MECHANISM OF MALONYLDIALDEHYDE ON ERYTHROCYTESA HEMOLYSIS[J].Chinese Journal of Biochemistry and Molecular Biology,1987,3(3):207-211. |
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| Authors: | Yin Chang-cheng Pan Hua-zhen |
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| Institution: | Institute of Basic Medical Sciences |
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| Abstract: | Malonyldialdehyde (MDA) is a product of lipid peroxidation. In vitro studies on the mechanism of hemolysis induced by MOA have shown that MDA react with phospholipids, particularly phosphatidyl ethanolamine and phosphatidyl serine to produce three fluorecent substances. Another important event is that MDA may also react with hqmoglobin to form a hemolytic substance which has been identified as ferriprotoporphyrin. The possible mechanism of homolysis induced by lipid peroxidation through the action of MDA has been discussed.scussed. |
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| Keywords: | lipid peroxidation malonyldialdehyde phospholipids hemolysis |
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