Characterization of phosphoinositide hydrolysis products induced by hexachlorocyclohexane isomers in rat brain cortex |
| |
Authors: | N del Hoyo J A Pulido M A Pérez-Albarsanz |
| |
Institution: | (1) Departmento de Bioquímica y Biologia Molecular, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain |
| |
Abstract: | Water-soluble inositol metabolites were separated by anion-exchange chromatogrphy in order to determine whether or not -hexachlorocyclohexane (-HCH, lindane) and related compounds affect phosphatidylinositol hydrolysis in rat brain cortex slices. Hydrolysis was increased by -and -HCH, while - and -HCH were inactive. Muscarinic receptor stimulation of rat cortical slices with carbachol increases inositol phosphates formation. The combined effect of carbachol and the hexachlorocyclohexane isomers together were approximately equal to the sum of the effect of each one separately. The results suggest that lindane stimulates phosphoinositide phospholipase C and/or inhibits the phosphases implicated in dephosphorylation of inositol phosphates. |
| |
Keywords: | hexachlorocyclohexane isomers inositol phosphates brain cortex (rat) |
本文献已被 SpringerLink 等数据库收录! |