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Metalloporphyrins as chemical mimics of cytochrome P-450 systems |
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| Authors: | Mukund S. Chorghade Derek A. Dezaro David R. Hill Elaine C. Lee Richard J. Pariza Jan V. Andersen Kristian T. HansenDavid H. Dolphin |
| Affiliation: | Abbot Laboratories, North Chicago, Illinois 60064 U.S.A. Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Máløv Denmark University of British Columbia, Vancouver, British Columbia, V6T1Y6 Canada |
| Abstract: | Certain synthetic metalloporphyrins have been shown to mimic the in vivo metabolism of some pharmaceuticals. Oxidation, hydroxylation and N-demethylation yielded synthetic metabolites. If found to be general, this lays the foundation of a predictive basis to optimize analog desing of inhibitors with reduced oxidative reactivity, to determine the proclivity of drugs to form biological active metabolites, and provides a convenient methodology for their preparation. Certain Synthetic metalloporphyrins have been shown to mimic the in vivo metabolism of some pharmaceuticals. Oxidation. hydroxylation and N-demethylation yielded synthetic metabolites. If found to be general, this lays the foundation of a predictive basis to optimize analog design of inhibitors with reduced oxidative reactivity, to determine the proclivity of drugs to form biologically active metabolites, and provides a convenient methodology for their preparation. |
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