Purification of alpha2-macroglobulin and the construction of immunogenic alpha2-macroglobulin-peptide complexes for use as cancer vaccines |
| |
| Authors: | Binder Robert J |
| |
| Affiliation: | Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, CT 06030-1601, USA. Rbinder@up.uchc.edu |
| |
| Abstract: | A simple method for purification of immunogenic alpha2-macroglobulin from murine serum is described. Also described is a method for creating alpha2-macroglobulin-antigen complexes using purified alpha2-macroglobulin and peptides derived from tumor cell lysates. The application of such alpha2-macroglobulin-antigen complexes for eliciting cancer immunity is discussed. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
