| 线粒体融合蛋白2研究新进展 |
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| 引用本文： | 赵光举,卢中秋,姚咏明.线粒体融合蛋白2研究新进展[J].生物化学与生物物理进展,2010,37(3):252-260. |
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| 作者姓名： | 赵光举 卢中秋 姚咏明 |
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| 作者单位： | 温州医学院附属第一医院急诊科;解放军总医院第一附属医院全军烧伤研究所; |
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| 基金项目： | 国家重点基础研究发展计划(2005CB522602); 国家自然科学基金(30672178,30872683)资助项目; 浙江省医学扶植重点建设学科计划(07-F04)~~ |
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| 摘 要： | 线粒体融合蛋白2(mitofusin-2,Mfn2)是一种高度保守的跨膜GTP酶,在线粒体融合中的关键作用已为人所熟知.随着认识的不断深入,Mfn2在介导线粒体融合之外的功能日渐显现,其在细胞信号转导、能量代谢、增殖及凋亡等生命过程中均具有重要调节作用.Mfn2效应的广泛性及作用机制的复杂性预示着其在现代生物医学中可能极具应用价值.综述了Mfn2结构和生物学功能研究的最新认识,并简要介绍了Mfn2功能或表达异常与疾病发生的关系及其治疗学意义.
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| 关 键 词： | 线粒体 线粒体融合蛋白2 信号转导 凋亡 疾病 |
| 收稿时间： | 2009/9/14 0:00:00 |
| 修稿时间： | 2009/11/23 0:00:00 |
Research Progress of Mitofusin-2 |
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| ZHAO Guang-Ju,LU Zhong-Qiu and YAO Yong-Ming.Research Progress of Mitofusin-2[J].Progress In Biochemistry and Biophysics,2010,37(3):252-260. |
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| Authors: | ZHAO Guang-Ju LU Zhong-Qiu and YAO Yong-Ming |
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| Institution: | ZHAO Guang-Ju1),LU Zhong-Qiu1)**,YAO Yong-Ming2)** (1) Emergency Department,The First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China,2) Burns Institute,First Hospital Affiliated to The Chinese PLA General Hospital,Beijing 100048,China) |
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| Abstract: | Mitofusin-2 (Mfn2) is a highly conserved transmembrane GTPase which plays a critical role in mitochondrial fusion process. Recent data have been demonstrated that Mfn2 is involved in the regulation of several crucial cellular pathways beyond fusion, including mitochondrial metabolism, cellular signaling cascade, apoptosis and proliferation. With multiple functions and complex mechanisms, Mfn2 might play potential role in the applications in modern medicine. The structure and basic biological function of Mfn... |
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| Keywords: | mitochondria mitofusin-2 signal transduction apoptosis disease |
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