A synthetic method for peptide-PEG-lipid conjugates: application of octreotide-PEG-DSPE synthesis |
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| Authors: | Su Jian-Chiou Tseng Chin-Lu Chang Ting-Gung Yu Wen-Jen Wu Shih-Kwang |
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| Affiliation: | Department of Medical Research, Kuang Tien General Hospital, 5-2, Datong Street, Shalu, Taichung 43353, Taiwan, ROC. |
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| Abstract: | A solid phase synthesis method was established for the synthesis of peptide-poly(ethylene glycol)-lipid (peptide-PEG-lipid) conjugates. Octreotide-PEG(2000)-DSPE (OPD(2000)) was used as an example to demonstrate the synthetic approach. The OPD(2000) obtained had confirmed structure, activity, and purity providing a targeting molecule for preparation of well-defined drug delivery systems, such as targeted liposomes, for further studies. |
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