Quinuclidines as selective agonists for alpha-7 nicotinic acetylcholine receptors |
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| Authors: | Leonik Fedra M Papke Roger L Horenstein Nicole A |
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| Affiliation: | Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. |
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| Abstract: | The alpha7 subtype of the neuronal nicotinic acetylcholine receptors (nAChRs) was targeted for the design of selective agonists deriving from the quinuclidine scaffold. Arylidene groups at the 3-position and N-methyl quinuclidine were found to be selective agonists with EC(50)s of 1.5 and 40 microM, respectively. |
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