Regional volume changes in canine lungs suspended in air |
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Authors: | Abbrecht P H Kyle R R Bryant H J Feuerstein I |
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Affiliation: | Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. |
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Abstract: | The purpose of this study was to determine the effect of the absence of a pleural pressure gradient (simulating the presumed condition found in microgravity) upon regional expansion of the lung. We attempted to produce a uniform pressure over the surface of the lung by suspending excised lungs in air. Such studies should help determine whether or not absence of a pleural pressure gradient leads to uniform ventilation. A preparation in which there is no pleural pressure gradient should also be useful in studying non-gravitational effects on ventilation distribution. |
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