Uncarinic acids: phospholipase Cgamma1 inhibitors from hooks of Uncaria rhynchophylla. |
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| Authors: | J S Lee M Y Yang H Yeo J Kim H S Lee J S Ahn |
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| Affiliation: | College of Pharmacy, Seoul National University, Korea. |
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| Abstract: | Bioactivity-guided fractionation of the CHCl3 extract from hooks of Uncaria rhynchophylla led to the isolation of two triterpene esters, namely uncarinic acids A (1) and B (2). Their structures were established by spectroscopic and chemical methods. These compounds inhibited phospholipase Cgamma1 with IC50 values of 35.66 and 44.55 microM, respectively. |
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