| 肿瘤抑制因子p53功能及其抗病毒作用研究进展 |
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| 引用本文： | 晏文君,吴开宝,马志永. 肿瘤抑制因子p53功能及其抗病毒作用研究进展[J]. 病毒学报, 2012, 28(4): 462-470 |
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| 作者姓名： | 晏文君 吴开宝 马志永 |
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| 作者单位： | 中国农业科学院上海兽医研究所,上海,200241;南京农业大学 动物医学院,南京,210095 |
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| 基金项目： | 转基因生物新品种培育科技重大专项(2009ZX08010-022B);上海市基础研究重点项目(10JC1417300) |
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| 摘 要： | 肿瘤抑制因子p53 作为基因组的守护者，能通过细胞周期调控和促进细胞凋亡而阻止癌细胞及机体肿瘤的发生，p53还能参与DNA损伤修复、调节机体代谢及调节繁殖生育等功能。除此以外，近年来研究发现，p53能通过促进病毒感染的细胞凋亡而起到抗病毒作用以及p53受IFN的调控和p53作为转录调控因子还能直接转录激活IRF9、IRF5、ISG15和TLR3等抗病毒基因，从而确定了p53在抗病毒反应中起到重要作用。这表明p53可能参与先天性免疫、获得性免疫及炎症反应而起到抗病毒的作用。
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| 关 键 词： | p53 抗病毒免疫 |
Function of Tumor Suppressor p53 and its Role in Antiviral Immunity |
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| YAN Wen-jun,WU Kai-bao,MA Zhi-yong. Function of Tumor Suppressor p53 and its Role in Antiviral Immunity[J]. Chinese journal of virology, 2012, 28(4): 462-470 |
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| Authors: | YAN Wen-jun WU Kai-bao MA Zhi-yong |
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| Affiliation: | 1(1.Shanghai Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Shanghai 200241,China; 2.College of Veterinary Medicine,Nanjing Agricultural University,Nanjing 210095,China) |
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| Abstract: | Tumor suppressor p53,known as ’the guardian of the genome’,has the ability to prevent the emergence of transformed cells by the induction of cell cycle arrest and apoptosis.Otherwise,there were researches about the function of p53,such as NDA repair,regulating metabolism and maternal reproduction in recent years.Furthermore,there was a new function for p53 in antiviral apoptosis mentioned in the research,Integration of interferon-alpha/beta signaling to p53 responses in tumour suppression and antiviral defense.In order to define the antiviral function of p53,many target genes has been defined,such as IRF9,IRF5,ISG15 and TLR3.All of these implied there must be a complex mechanism for role of p53 in antiviral innate immunity,adaptive immunity and inflammation. |
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| Keywords: | p53 Antiviral immunity |
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