A rapid-kinetic study of the class C beta-lactamase of Enterobacter cloacae 908R. |
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| Authors: | D Monnaie R Virden J M Frère |
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| Affiliation: | Laboratoire d'enzymologie, Université de Liège, Belgium. |
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| Abstract: | The individual rate constants for acylation and deacylation (k2 and k3, respectively) of the class C beta-lactamase of Enterobacter cloacae 908R by ampicillin and carbenicillin have been determined. For several other beta-lactams, the value of k2 was too high to be determined and the k2/k3 ratio could be larger than 10,000. Branched pathways were also shown to occur with several penicillins and cephalosporins. |
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