The inflammasome: first line of the immune response to cell stress |
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Authors: | Ogura Yasunori Sutterwala Fayyaz S Flavell Richard A |
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Institution: | Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. |
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Abstract: | The NALP3-inflammasome is a protein complex that stimulates caspase-1 activation to promote the processing and secretion of proinflammatory cytokines. Recent work indicates that the NALP3-inflammasome can be activated by endogenous "danger signals" as well as compounds associated with pathogens (Kanneganti et al., 2006; Mariathasan et al., 2006, Martinon et al., 2006; Sutterwala et al., 2006). Here, we discuss new insights into the regulation of caspase-1 activity in the inflammatory response. |
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