Role of enzymes and inhibitors in leu-enkephalin metabolism in rabbit and human plasma |
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Authors: | Francesca Bolacchi Mario Marini Alessandra Urbani Lucilla Bongiorno L Giorgio Roda |
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Institution: | (1) Dipartimento di Medicina Sperimentale, Universita' degli Studi di Roma “Tor Vergata”, Via di Tor Vergata 135, 00133 Roma, Italy |
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Abstract: | The hydrolysis of leucine enkephalin by the proteolytic enzymes present in human and rabbit plasma has been studied by kinetic
and chromatographic techniques. Data obtained indicate the existence of noticeable intraspecific differences in the kinetics
of leu-enkephalin degradation, and of formation of its hydrolysis by-products. The separation of the enzymes active on the
substrate and of the inhibitors active on these enzymes evidences the existence of a species specific distribution of both
groups of substances. Yet, the dissimilar kinetics of the substrate hydrolysis and of formation of its hydrolysis by-products
appear to arise more from diversities in the competition between the enzymes present in plasma and in the role of inhibitors
than from the differences in the enkephalin-degrading enzymes. It is suggested that differences observed may be related to
the existence of species specific populations of the information-carrying plasma peptides. |
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Keywords: | Leu-enkephalin enzymes inhibitors metabolism |
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