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Sex differences in the immune response to acute COVID-19 respiratory tract infection |
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| Authors: | Qi Shaohua Ngwa Conelius Morales Scheihing Diego A. Al Mamun Abdullah Ahnstedt Hilda W. Finger Carson E. Colpo Gabriela Delevati Sharmeen Romana Kim Youngran Choi HuiMahn A. McCullough Louise D. Liu Fudong |
| Affiliation: | 1.Section of Endocrinology and Metabolism, Deming Department of Medicine, Tulane University School of Medicine, 1430 Tulane Ave. SL53, New Orleans, LA, 70112, USA ;2.Southeast Louisiana Veterans Affairs Healthcare System, New Orleans, LA 70119, USA ;3.Deming Department of Medicine, Tulane University School of Medicine, 1430 Tulane Ave. SL53, New Orleans, LA, 70112, USA ;4.Department of Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, 1430 Tulane Ave. SL53, New Orleans, LA, 70112, USA ;5.Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1430 Tulane Ave. SL53, New Orleans, LA, 70112, USA ;6.Section of Pulmonary Diseases, Critical Care, and Environmental Medicine, Deming Department of Medicine Tulane University School of Medicine, 1430 Tulane Ave. SL53, New Orleans, LA, 70112, USA ; |
| Abstract: | Determine if sex differences exist in clinical characteristics and outcomes of adults hospitalized for coronavirus disease 2019 (COVID-19) in a US healthcare system. Case series study. Sequentially hospitalized adults admitted for COVID-19 at two tertiary care academic hospitals in New Orleans, LA, between 27 February and 15 July 2020. Measures included demographics, comorbidities, presenting symptoms, and laboratory results. Outcomes included intensive care unit admission (ICU), invasive mechanical ventilation (IMV), and in-hospital death. We included 776 patients (median age 60.5 years; 61.4% women, 75% non-Hispanic Black). Rates of ICU, IMV, and death were similar in both sexes. In women versus men, obesity (63.8 vs 41.6%, P < 0.0001), hypertension (77.6 vs 70.1%, P = 0.02), diabetes (38.2 vs 31.8%, P = 0.06), chronic obstructive pulmonary disease (COPD, 22.1 vs 15.1%, P = 0.015), and asthma (14.3 vs 6.9%, P = 0.001) were more prevalent. More women exhibited dyspnea (61.2 vs 53.7%, P = 0.04), fatigue (35.7 vs 28.5%, P = 0.03), and digestive symptoms (39.3 vs 32.8%, P = 0.06) than men. Obesity was associated with IMV at a lower BMI (> 35) in women, but the magnitude of the effect of morbid obesity (BMI ≥ 40) was similar in both sexes. COPD was associated with ICU (adjusted OR (aOR), 2.6; 95%CI, 1.5–4.3) and IMV (aOR, 1.8; 95%CI, 1.2–3.1) in women only. Diabetes (aOR, 2.6; 95%CI, 1.2–2.9), chronic kidney disease (aOR, 2.2; 95%CI, 1.3–5.2), elevated neutrophil-to-lymphocyte ratio (aOR, 2.5; 95%CI, 1.4–4.3), and elevated ferritin (aOR, 3.6; 95%CI, 1.7–7.3) were independent predictors of death in women only. In contrast, elevated D-dimer was an independent predictor of ICU (aOR, 7.3; 95%CI, 2.7–19.5), IMV (aOR, 6.5; 95%CI, 2.1–20.4), and death (aOR, 4.5; 95%CI, 1.2–16.4) in men only. This study highlights sex disparities in clinical determinants of severe outcomes in COVID-19 patients that may inform management and prevention strategies to ensure gender equity. |
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