The Absence of M1 Leads to Increased Establishment of Murine Gammaherpesvirus 68 Latency in IgD-Negative B Cells |
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| Authors: | Laurie T Krug Andrew G Evans Lisa M Gargano Clinton R Paden Samuel H Speck |
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| Institution: | aEmory Vaccine Center;bDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA;cDepartment of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA |
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| Abstract: | The secreted M1 protein of murine gammaherpesvirus 68 (MHV68) promotes effector Vβ4+ CD8+ T cell expansion to impact virus control and immune-mediated pathologies in C57BL/6 mice, but not BALB/c mice. We report a striking increase in the number of genome-positive, IgD− B cells during chronic infection of both mouse strains. This suggests a novel role for M1 in influencing long-term maintenance in a major latency reservoir irrespective of the degree of Vβ4+ CD8+ T cell expansion. |
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