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H2A Ubiquitination Alters H3-tail Dynamics on Linker-DNA to Enhance H3K27 Methylation

Institution:	1. Graduate School of Medical Life Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan;2. Laboratory of Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan;3. Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, 23 Innovation Walk, Clayton, VIC 3800, Australia;4. RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan;5. EMBL-Australia, Clayton, VIC 3800, Australia;6. Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan;7. Graduate School of Integrated Sciences for Life, Hiroshima University, 1-4-4 Kagamiyama, Higashi-Hiroshima 739-8258, Japan

Abstract:

Keywords:	histone tail H2A ubiquitination NMR polycomb repressive complex H3K27 methylation HSQC"} {"#name":"keyword" "$":{"id":"k0035"} "$$":[{"#name":"text" "_":"heteronuclear single-quantum coherence spectroscopy NOE"} {"#name":"keyword" "$":{"id":"k0045"} "$$":[{"#name":"text" "_":"nuclear Overhauser effect cryo-EM"} {"#name":"keyword" "$":{"id":"k0055"} "$$":[{"#name":"text" "_":"cryogenic electron microscope PRC"} {"#name":"keyword" "$":{"id":"k0065"} "$$":[{"#name":"text" "_":"polycomb repressive complex UIM"} {"#name":"keyword" "$":{"id":"k0075"} "$$":[{"#name":"text" "_":"ubiquitin interaction motif PCL"} {"#name":"keyword" "$":{"id":"k0085"} "$$":[{"#name":"text" "_":"Polycomb-like MD"} {"#name":"keyword" "$":{"id":"k0095"} "$$":[{"#name":"text" "_":"molecular dynamics FRET"} {"#name":"keyword" "$":{"id":"k0105"} "$$":[{"#name":"text" "_":"Förster resonance energy transfer NCP"} {"#name":"keyword" "$":{"id":"k0115"} "$$":[{"#name":"text" "_":"nucleosome core particles HDX-MS"} {"#name":"keyword" "$":{"id":"k0125"} "$$":[{"#name":"text" "_":"hydrogen–deuterium exchange mass spectrometry NMR"} {"#name":"keyword" "$":{"id":"k0135"} "$$":[{"#name":"text" "_":"nuclear magnetic resonance BS"} {"#name":"keyword" "$":{"id":"k0145"} "$$":[{"#name":"text" "_":"basic segment
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