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The human pre-replication complex is an open complex
Affiliation:1. School of Biological Sciences, The University of Hong Kong, Hong Kong, China;2. Division of Life Science, Center of Systems Biological and Human Health, The Hong Kong University of Science and Technology, Hong Kong, China;3. Institut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne Université, 75005 Paris, France;4. State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong, China;5. Biological Cryo-EM Center, The Hong Kong University of Science and Technology, Hong Kong, China;6. Institute for Advanced Study, The Hong Kong University of Science and Technology, Hong Kong, China;7. Department of Molecular Biology & Genetics, Cornell University, Ithaca, NY 14853, USA;8. Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, China;9. HKUST-Shenzhen Research Institute, Nanshan, Shenzhen 518057, China
Abstract:
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  • Keywords:DNA replication initiation  pre-RC  human MCM2–7 complex  replication licensing  origin firing  initial DNA melting
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