Caveolin-1 Expression Level in Cancer Associated Fibroblasts Predicts Outcome in Gastric Cancer |
| |
| Authors: | Xianda Zhao Yuyu He Jun Gao Lifang Fan Zonghuan Li Guifang Yang Honglei Chen |
| |
| Affiliation: | 1. Department of Pathology, School of Basic Medical Science, Wuhan University, Wuhan, P. R. China.; 2. Department of Molecular Pathology, Wuhan Nano Tumor Diagnosis Engineering Research Center, Wuhan, P. R. China.; 3. Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, P. R. China.; 4. Department of Biochemistry, Rush University Medical Center, Chicago, Illinois, United States of America.; Vanderbilt University Medical Center, United States of America, |
| |
| Abstract: | AimsAltered expression of epithelial or stromal caveolin-1 (Cav-1) is observed in various types of human cancers. However, the clinical significance of Cav-1 expression in gastric cancer (GC) remains largely unknown. The present study aims to explore the clinicopathological significance and prognostic value of both tumor cells and cancer associated fibroblasts (CAFs) Cav-1 in GC.Methods and ResultsQuantum dots immunofluorescence histochemistry was performed to examine the expression of Cav-1 in 20 cases of gastritis without intestinal metaplasia (IM), 20 cases of gastritis with IM and 286 cases of GC. Positive rates of epithelial Cav-1 in gastritis without IM, gastritis with IM and GC showed a decreasing trend (P = 0.012). Low expression of Cav-1 in CAFs but not in tumor cells was an independent predictor of poor prognosis in GC patients (P = 0.034 and 0.005 respectively in disease free survival and overall survival). Cav-1 level in tumor cells and CAFs showed no significant correlation with classic clinicopathological features.ConclusionsLoss of epithelial Cav-1 may promote malignant progression and low CAFs Cav-1 level herald worse outcome of GC patient, suggesting CAFs Cav-1 may be a candidate therapeutic target and a useful prognostic marker of GC. |
| |
| Keywords: | |
|
|
