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Loss of epigenetic information as a cause of mammalian aging
Institution:1. Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA;2. Department of Ophthalmology, Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan;3. IIIUC-Institute of Interdisciplinary Research, University of Coimbra, Coimbra, Portugal;4. Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA;5. Cantata/Dovetail Genomics, Scotts Valley, CA, USA;6. Zymo Research Corporation, Irvine, CA, USA;7. Department of Medicine, Brigham and Women’s Hospital, HMS, Boston, MA, USA;8. Division of Nephrology, University of Washington, Seattle, WA, USA;9. Georgetown University School of Medicine, Washington, DC, USA;10. Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA;11. Experimental Gerontology Section, NIA/NIH, Baltimore, MD, USA;12. Department of Pharmacology, UNSW, Sydney, NSW, Australia;13. Department of Biomolecular Engineering, UCSC, Santa Cruz, CA, USA;14. Department of Stem Cell Biology, Tokyo Medical and Dental University, Tokyo, Japan;15. Vium, San Mateo, CA, USA;16. Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, HMS, Boston, MA, USA;17. The Massachusetts General Hospital Cancer Center, HMS, Boston, MA, USA;18. Department of Genetics, HMS, Boston, MA, USA;19. Department of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty, University of Heidelberg, BioQuant, Heidelberg, Germany;20. Paul F. Glenn Center for Biology of Aging Research, Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA;21. Division of Geriatrics, University of Nebraska Medical Center, Durham Research Center II, Omaha, NE, USA;22. Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal;23. Department of Pathology, University of Washington, Seattle, WA, USA;24. Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA;25. Department of Pathology, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, USA;26. Laboratory of Receptor Biology and Gene Expression, NCI, NIH, Bethesda, MD, USA;27. Joslin Diabetes Center, Boston, MA, USA
Abstract:
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  • Keywords:DNA damage  chromatin  aging  epigenetic clock  epigenetic reprogramming  senescence  relocalization of chromatin modifier  RCM
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