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Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan
Institution:1. The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK;2. Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK;3. Department of Biochemistry, Charité – Universitätsmedizin Berlin, 10117 Berlin, Germany;4. Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Eötvös Loránd Research Network, Szeged 6726, Hungary;5. HCEMM-BRC Metabolic Systems Biology Lab, Szeged 6726, Hungary;6. Precision Proteomics Center, Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, 7265 Davos, Switzerland;7. The Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK;8. Core Facility – High Throughput Mass Spectrometry, Charité – Universitätsmedizin Berlin, 10117 Berlin, Germany;9. Quantitative Gene Expression Research Group, MRC London Institute of Medical Sciences (LMS), London W12 0HS, UK;10. Quantitative Gene Expression Research Group, Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London SW2 2AZ, UK;11. Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden;12. Randall Centre for Cell & Molecular Biophysics, King’s College London, New Hunt’s House, Guy’s Campus, London SE1 1UL, UK;13. Institute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius 10257, Lithuania;14. Department of Biology, College of Science, United Arab Emirates University, P.O.Box 15551, Al-Ain, United Arab Emirates
Abstract:
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  • Keywords:metabolite exchange interactions  chronological aging  metabolic microenvironment  eukaryotic longevity
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