Sequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear |
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| Authors: | Luca Jovine Jong Park Paul M Wassarman |
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| Affiliation: | (1) Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029-6574, USA;(2) MRC Dunn Human Nutrition Unit, Hills Road, Cambridge, CB2 2XY, UK |
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| Abstract: | Background Interaction between hair cells and acellular gels of the mammalian inner ear, the tectorial and otoconial membranes, is crucial for mechanoreception. Recently, otoancorin was suggested to be a mediator of gel attachment to nonsensory cells, but the molecular components of the interface between gels and sensory cells remain to be identified. |
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