Synthesis and biological characterisation of [3H]BBL454, a new CCK2 selective radiolabelled agonist displaying original pharmacological properties |
| |
Authors: | Bellier Bruno Dugave Christophe Etivant Frédéric Genet Roger Gigoux Véronique Garbay Christiane |
| |
Affiliation: | Laboratoire de Pharmacochimie Moléculaire et Structurale, FRE CNRS 2463-INSERM U266, UFR des Sciences Pharmaceutiques et Biologiques, 4 avenue de l'Observatoire, 75270 Cedex 06, Paris, France. |
| |
Abstract: | [(3)H]BBL454, a new CCK(2) selective tritiated agonist was prepared via the reductive tritiation of a 5-aminopentyn-1-yl moiety introduced on the N-terminal end of a pentapeptide derivative of cholecystokinin. The binding properties of this labelled compound were determined on CHO cells transfected with the rat CCK(2) receptor. [(3)H]BBL454 is able to discriminate two affinity states of the CCK(2) receptor a supplementary indication of its validity for further exploring the heterogeneity of this receptor. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|