Apoptosis induced by BIK was decreased with RNA interference of caspase-12 |
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| Authors: | Zhao Xiaoping Sun Yan Yu Hai Ye Ling Zhang Leilei Lu Jian Yuan Yaozong Qian Guanxiang Ge Shengfang |
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| Affiliation: | Research Center for Human Gene Therapy, Department of Biochemistry and Molecular Biology, School of Medicine, Shanghai Jiao Tong University, No. 280 Chongqing Road South, Shanghai 200025, China. |
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| Abstract: | BIK, a member of the Bcl-2 family, has been reported to induce cell apoptosis but the underlying mechanisms are not well delineated. We used siRNA targeting caspase-12 to examine the effect of caspase-12 on apoptosis induced by BIK. In this study, we show that caspase-12 was activated by BIK. With caspase-12 knocked down, the apoptosis induced by BIK was decreased substantially. The activation of caspase-9 and depolarization of mitochondrial membrane potential were induced by BIK, which were decreased concomitant with caspase-12 silenced. |
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| Keywords: | AhR PPARα Inflammation Gut Caco-2 |
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