Hyperglycaemia,oxidative stress and inflammatory markers |
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| Authors: | Eugene G. Butkowski Herbert F. Jelinek |
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| Affiliation: | 1. School of Community Health, Charles Sturt University, Albury, Australia;2. School of Medicine, University of New South Wales, Sydney, Australia;3. Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia |
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| Abstract: | Introduction: The increasing prevalence of hyperglycaemia implicates a state of oxidative stress and inflammation. Traditional and emerging biomarkers associated with increasing hyperglycaemia were assessed to clarify their role they play in hyperglycaemia.Results: 309 participants attending a rural diabetic screening program were categorised into control and quintile groups based upon glucose levels: 1st quintile - <4.5?mmol/L and 4th, 5th quintile - >6.1?mmol/L. Significant results were obtained for anthropometric data and biochemical markers - glucose, HbA1c and total cholesterol (P?P?P?P?Conclusion: This study provided further evidence that inflammatory and oxidative stress biomarkers may contribute to diagnostic information associated with preclinical increases in BGL. Further we have provided a unique study in the analysis of ratios of inflammatory biomarkers and correlations with increasing BGL. |
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| Keywords: | Type 2 diabetes mellitus impaired fasting glucose prediabetes cardiovascular disease oxidative stress risk factors body mass index glutathione glutathione disulphide 8-hydroxy-2′-deoxyguanosine interleukin 1β interleukin-6 interleukin 10 monocyte chemoattractant protein 1 insulin like growth factor 1 |
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