Alteration of thiol-disulphide homeostasis in acute tonsillopharyngitis |
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Authors: | Soner Sertan Kara Ozcan Erel Tugba Bedir Demirdag Burcu Ceylan Cura Yayla Belgin Gulhan Salim Neselioglu |
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Institution: | 1. Department of Pediatric Infectious Diseases, Gazi University Medical Faculty, Ankara, Turkey;2. Department of Biochemistry, Yildirim Beyazit University Medical Faculty, Ankara, Turkey;3. Department of Pediatric Infectious Diseases, Ankara Hematology Oncology Children's Training and Research Hospital, Ankara, Turkey |
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Abstract: | Objective: Thiol-disulphide homeostasis (TDH) has a critical role in various clinical disorders. We aimed to assess the association of TDH with acute tonsillopharyngitis (AT) in children.Methods: This study included 94 (73 viral and 21 bacterial) tonsillopharyngitis patients and 88 control children. Their native thiol, total thiol, and disulphide levels were measured.Results: Viral and bacterial tonsillopharyngitis patients had lower native thiol levels compared with healthy children (P?0.001 and P?=?0.008, respectively). Both groups had lower total thiol levels compared with control children (P?=?0.002 for viral, P?=?0.011 for bacterial). The disulphide levels were lower in bacterial than in viral tonsillopharyngitis patients (P?=?0.04), and there was a significant difference between viral tonsillopharyngitis patients and the control group (P?0.001). The native/total thiol ratio in each patient group was lower than in the control group (P?0.001 for viral, P?=?0.017 for bacterial). The disulphide/native thiol and disulphide/total thiol ratios were significantly higher in viral (P?0.001 for both) and bacterial tonsillopharyngitis patients (P?=?0.017 for both) than in healthy children. In all patients, a correlation was found between the levels of C-reactive protein (CRP) and native thiol (r?=??0.211, P?=?0.04), CRP and total thiol (r?=??0.217, P?=?0.036), white blood cell (WBC) and native thiol (r?=??0.228, P?=?0.002), WBC and total thiol (r?=??0.191, P?=?0.01), and WBC and disulphide (r?=?0.160, P?=?0.03).Discussion: TDH is altered in AT in children. The alteration is more prominent in viral than in bacterial tonsillopharyngitis. |
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Keywords: | Acute tonsillopharyngitis Children Thiol-disulphide homeostasis |
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