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R-SPONDIN2+ mesenchymal cells form the bud tip progenitor niche during human lung development
Institution:1. Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA;2. Department of Internal Medicine, Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA;3. Program in Cell and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA;5. Columbia Center for Human Development, Columbia Stem Cell Initiative, Departments of Medicine and Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA;6. Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA;7. Department of Pediatrics, Genetic Medicine, University of Washington, Seattle, WA 98195, USA;8. Laboratory of Human Genetics & Therapeutics, Institute of Molecular and Cell Biology (IMCB), A1STAR, Singapore;9. Medical Genetics Department, Koç University School of Medicine (KUSOM), Istanbul, Turkey;10. Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, MI 48109, USA
Abstract:
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  • Keywords:lung development  human development  single-cell RNA-seq  R-Spondin2  RSPO2  bud tip progenitor  lung mesenchyme  mesenchymal cell  stem cell niche  lung organoid
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