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DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism
Affiliation:1. National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK;2. The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW7 3RP, UK;3. Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK;4. Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA;5. CR-CHUM, Université de Montréal, R08-420, 800 Rue St. Denis, Montreal, H2X 0A9 QC, Canada;6. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 639798, Singapore;7. Department of Biomedical Science, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK
Abstract:
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  • Keywords:pluripotency  apoptosis  mitochondrial dynamics  mitophagy  early development  embryonic stem cell differentiation
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