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Reconstitution of human adrenocortical specification and steroidogenesis using induced pluripotent stem cells
Affiliation:1. Department of Biomedical Sciences, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA 19104, USA;2. Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;3. Bell Research Center for Reproductive Health and Cancer, Nagoya 460-0003, Japan;4. Department of Biochemistry and Biophysics, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA 19104, USA;5. Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;6. Center of Excellence in Environmental Toxicology, University of Pennsylvania, Philadelphia, PA 19104, USA;7. Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA;8. Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;9. Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;10. Division of Metabolism, Endocrinology, and Diabetes, Departments of Internal Medicine and Pharmacology, University of Michigan, Ann Arbor, MI 48105, USA;11. Department of Obstetrics and Gynecology, University of Pennsylvania, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;12. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA
Abstract:
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  • Keywords:adrenal cortex  fetal zone  definitive zone  intermediate mesoderm  human-induced pluripotent stem cells  steroidogenesis  adrenocortical development  adrenal capsule  adrenocorticotropic hormone  NR5A1
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