Fatty Acid Spectra of Pediococcus urinae-Equi,P. homari Comparing with Other Pediococci |
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| Authors: | Kinji Uchida Koya Mogi |
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| Affiliation: | Central Research Laboratories Kikkoman Shoyu Co., Ltd. |
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| Abstract: | A new biological activity of 6-(methylsulfinyl)hexyl isothiocyanate derived from Wasabia japonica was discovered as an inhibitor of glycogen synthase kinase-3β. The most potent isothiocyanate, 9-(methylsulfinyl)hexyl isothiocyanate, inhibited glycogen synthase kinase-3β at a Ki value of 10.5 μM and showed ATP competitive inhibition. The structure-activity relationship revealed an inhibitory potency of methylsulfinyl isothiocyanate dependent on the alkyl chain length and the sulfoxide, sulfone, and/or the isothiocyanate moiety. |
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| Keywords: | wasabi Wasabia japonica Matsum methylsulfinyl isothiocyanate GSK-3β |
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