Isolation of Festuclavine and Three New Indole Alkaloids,Roquefortine A,B and C from the Cultures of Penicillium roqueforti |
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Authors: | Sadahiro Ohmomo Takao Sato Teiichi Utagawa Matazo Abe |
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Institution: | Laboratory of Industrial Microbiology, Faculty of Agriculture, Tokyo University of Education, Komaba, Meguro-ku, Tokyo |
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Abstract: | The structure and absolute configuration of a metabolite isolated from Aspergillus silvaticus was studied by an X-ray diffraction method. Crystals were orthorhombic, with space group P212121, and a=9.894 (5), b = 6.803 (4), c=22.519 (6) Å, and Z=4. The structure was solved by a direct method and refined by a block-diagonal least-square method to R=0.07 for 1143 non-zero reflections. The metabolite was identified as naphthalic anhydride obtained from atrovenetin. The absolute configuration determined by the Bijvoet method is consistent with that shown chemically. The molecule has two intramolecular hydrogen bonds. |
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Keywords: | inositol requiring kinase 1 α (IRE1α) imaging bimolecular fluorescent complementation (BiFC) assay unfolded protein response (UPR) small molecule |
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