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Urocanic Acid Production by Sporogenous Bacteria
Authors:Hiroshi Imanaka
Affiliation:Tokyo Research Laboratory of Fujisawa Pharmaceutical Industries Ltd.Tokyo
Abstract:As the results of a screening of several type cultures of bacteria, Bacillus subtilis var. thermophilus was revealed to be the most powerful strain for urocanic acid production. The accumulation of urocanic acid by this bacteria is caused by deamination of L-histidine, and is particularly accelerated in the presence of a component (X-factor) in meat extract. In the decomposition of urocanic acid the optimal pH of urocanase activity is markedly inhibited by the deviation of pH of the culture medium. The histidase of this bacteria is supposed to be a new exo-type enzyme.
Keywords:misfolded protein  endoplasmic reticulum (ER)-associated degradation  carboxypeptidase Y  invertase  yeast
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