A New Synthetic Method of Methyl Ketones |
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| Authors: | Toshio Yoshida Akio Yamaguchi Akira Komatsu |
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| Institution: | Takasago Perfumery Co., Ltd., Tokyo, Japan |
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| Abstract: | A simple and stereospecific method has been developed for the synthesis of cis-jasmone. 3-Methyl-2-cyclopentenone (V) was condensed with cis-2-pentenyl chloride, which was prepared from propargyl alcohol, by means of sodium amide in liquid ammonia to yield stereochemically pure cis-jasmone (VIb) in 39~40% yield. By the similar direct alkylation, trans-jasmone (VIc) and dihydrojasmone (VIa) were also synthesized in moderate yields. |
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