Studies on the Synthesis of l-Amino Acids |
| |
Authors: | Masao Tanaka Teruo Kishi Shukuo Kinoshita |
| |
Institution: | Tokyo Research Lab., Kyowa Hakko Kogyo Co., Ltd., Tokyo |
| |
Abstract: | l-Homoserine was prepared by the reduction of l-aspartic acid β-methyl ester with sodium borohydride in water solution without any racemization. The yield of l-homoserine was about 25% of the theoretical amount, and no product other than l-homoserine, l-aspartic acid and l-aspartic acid β-methyl ester was present in the reaction mixture. The low yield of l-homoserine was ascribed to the hydrolysis of the ester.l-Azetidine-2-carboxylic acid could not be detected in the reaction mixture. In contrast with the reduction of l-glutamic acid γ-esters, the reduction of l-aspartic acid β-ester was not accompanied by the cyclization. |
| |
Keywords: | |
|
|