Purification and Properties of Alcohol Dehydrogenase from Tea Seeds |
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Authors: | Akikazu Hatanaka Takahiro Harada |
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Institution: | Department of Agricultural Chemistry, Yamaguchi University, Yamaguchi City 753, Japan |
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Abstract: | The process of antigen presentation is not well understood. We screened for drugs that distinguish presentation of allogeneic class 2 antigens and exogenous antigens. When spleen cells were used as antigen presenting cells (APC), leupeptin and antipain preferentially inhibited allogeneic class 2 presentation, while they did not affect presentation of exogenous antigen and T cell growth. In contrast, they inhibited both presentations when spleen adherent cells (SAC) were used as APC. Our results suggest that SAC (mainly macrophages) and splenic B cells use different pathways to present exogenous antigens and that pathways to present allogeneic class 2 molecules are similar. |
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