Studies on Nicotinoids1) as an Insecticide |
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| Authors: | Izuru Yamamoto Hideo Kamimura Ryo Yamamoto Seiroku Sakai Masayoshi Goda |
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| Institution: | 1. Laboratory of Pesticide Chemistry, Department of Agricultural Chemistry, Tokyo Agricultural University, Tokyo;2. Institute for Agricultural Chemicals, Yashima Chemical Industry Co., Ltd., Kawasaki |
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| Abstract: | Toxicities of some nicotinoids as an insecticide were determined. 5′-methylnornicotine, a new synthetic isomer of nicotine, shows similar toxicity to nicotine. The essential moiety in nicotinoids molecule responsible for high toxicity may be 3-pyridylmethylamine group, the amino nitrogen of which must have high basicity (pKa′: 7.4~9.0). All nicotinoids of high toxicity are estimated to be largely as monocation at physiological pH of 7. |
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