Synthesis and Toxicity of Allethrin-(Z)-metabolites |
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| Authors: | Takeyoshi Sugiyama Akio Kobayashi Kyohei Yamashita Takashi Suzuki |
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| Institution: | 1. Department of Agricultural Chemistry, Faculty of Agriculture, Tohoku University, Sendai;2. Research Department, Pesticides Division, Takarazuka Research Laboratory, Sumitomo Chemical Co., Ltd., Takarazuka, Hyogo |
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| Abstract: | (±)-trans-Allethrin-(Z)-ol (IV), (±)-trans-allethrin-(Z)-al (V) and (±)-trans-allethrin-(Z)-acid (VI), the minor components of allethrin metabolites in the insect body, were synthesized. The toxicities of newly synthesized allethrin derivatives (IV, V, VI) and of (±)-trans-allethrin-(E)-acid (Xc) to houseflies (Musca domestica L.) were examined by the injection method. And their low toxicities seem to support the hypothesis that oxidation at the isobutenyl side chain of the acid moiety of the allethrin molecule is a detoxication process in the insect body. |
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