An Alternate Synthesis of 2-(4-Isobutylphenyl)-propionic Acid |
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| Authors: | Katsura Kogure Kunio Nakagawa Hideaki Fukawa |
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| Affiliation: | Research Center, Nisshin Flour Milling Co., Ltd., Iruma District, Saitama |
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| Abstract: | 2-(4-Isobutylphenyl)-propionic acid, which is known to have a high anti-inflammatory activity and has widely been used in the treatment of diseases caused by inflammation, such as rheumatism, was synthesized from methyl 3-methyl-3-(4-isobutylphenyl)-glycidate, via methyl 2-hydroxy-3-(4-isobutylphenyl)-3-butenoate (VI) in four steps. |
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