PMR Study on the Absolute Structure of Kanamycins and Related Compounds |
| |
| Authors: | Akira Hasegawa Daikichi Nishimura Minoru Nakajima |
| |
| Institution: | 1. Department of Agricultural Chemistry, College of Agriculture, Kyoto University, Kyoto;2. Department of Agricultural Chemistry, College of Agriculture, Gifu University, Gifu |
| |
| Abstract: | The antioxidant behaviors of vitamin E and its analogues, 2, 2, 5, 7, 8-pentamethyl-6-hydroxychroman and l, 2-diacyl-sn-glycero-3-phospho-2?-(hydroxyethyl)-2?, 5?, 7?, 8?-tetramethyl-6?-hydroxychro-man, were studied in unilamellar vesicles. The two analogues scavenged aqueous radicals generated from azo compounds more efficiently than vitamin E. On the other hand, vitamin E scavenged the lipid peroxyl radicals preferentially. It is concluded that the superior antioxidant activity of vitamin E is attributed to its location suitable for breaking the chain propagation reaction. |
| |
| Keywords: | vitamin E antioxidant liposome oxidative stress |
|
|
