Unraveling the evolutionary history of the phosphoryl-transfer chain of the phosphoenolpyruvate:phosphotransferase system through phylogenetic analyses and genome context |
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Authors: | Iñaki Comas Fernando González-Candelas Manuel Zúñiga |
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Institution: | 1.Instituto Cavanilles de Biodiversidad y Biología Evolutiva,Universidad de Valencia,Valencia,Spain;2.Instituto de Agroquímica y Tecnología de Alimentos, CSIC,Valencia,Spain |
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Abstract: | Background The phosphoenolpyruvate phosphotransferase system (PTS) plays a major role in sugar transport and in the regulation of essential
physiological processes in many bacteria. The PTS couples solute transport to its phosphorylation at the expense of phosphoenolpyruvate
(PEP) and it consists of general cytoplasmic phosphoryl transfer proteins and specific enzyme II complexes which catalyze
the uptake and phosphorylation of solutes. Previous studies have suggested that the evolution of the constituents of the enzyme
II complexes has been driven largely by horizontal gene transfer whereas vertical inheritance has been prevalent in the general
phosphoryl transfer proteins in some bacterial groups. The aim of this work is to test this hypothesis by studying the evolution
of the phosphoryl transfer proteins of the PTS. |
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