Regional assignment of the gene locus for steroid sulfatase |
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| Authors: | C R Müller A Westerveld Beate Migl W Franke H H Ropers |
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| Institution: | (1) Institut für Humangenetik und Anthropologie, Albertstr. 11, D-7800 Freiburg, Federal Republic of Germany;(2) Department of Cell Biology and Genetics, Erasmus Universiteit, Postbus 1738, Rotterdam, The Netherlands |
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| Abstract: | Summary The gene locus for steroid sulfatase, deficiency of which causes X-linked ichthyosis, is assigned to Xp11 Xpter by analysis of 24 man-Chinese hamster somatic cell hybrids. High steroid sulfatase,activity in a hybrid clone having retained only part of Xq is explained by demonstration of an additional late-replicating human X chromosome. This observation confirms previous evidence for noninactivation of the STS locus. |
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