Effect of Escapable and Inescapable Stress on Levels of Catecholamines in Adrenals and Corticosterone in Blood Plasma in Young and Aged Rats |
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| Authors: | E. D. Bazhanova D. A. Zhukov S. Porta O. A. Danilova |
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| Affiliation: | (1) Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia;(2) Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia;(3) Institute of General and Experimental Pathology, University of Graz, Graz, Austria |
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| Abstract: | Effect of escapable and inescapable electrical stress (ES, IS) on the catecholaminergic system was studied in young (3 months) and aged (25 months) male Wistar rats on the day 3 after stress, using radioimmune analysis and high-pressure liquid chromatography. Catecholamine concentration in adrenals and corticosterone level in blood of control aged rats was lower than in young animals. On the third day after the electrical stimulation in cages with current-conducting floor, production of hormones of adrenal cortical and medullar layers rose significantly in aged rats, with a more pronounced increase of noradrenaline after IS, while of blood adrenaline and corticosterone, after ES. In young rats no significant changes in catecholamines were revealed, whereas the blood corticosterone level was increased after IS. Thus, in aged rats, a low basal level of catecholamines and corticosterone and a delayed stress response can be established. In old animals after ES, a long post-action was observed, which was quite comparable with the results obtained after IS in the both age groups. |
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