Self major histocompatibility complex class-II-specific regulatory CD4 T cells prevent both Th1- and Th2-mediated autoimmune diseases in the rat |
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| Authors: | Pelletier L Savignac M Xystrakis E Duplan V Druet P Abdelhadi S |
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| Affiliation: | Inserm U28, H?pital Purpan, place du D Baylac, 31059, Toulouse, France. Lucette.Pelletier@purpan.inserm.fr |
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| Abstract: | It is clear that functional heterogeneity of T cells may be explained by differential cytokine production. The aim of this paper was to review evidence for regulatory cells, generated after HgCl(2)-exposure. They differ from classical Th1 and Th2 cells, produce transforming growth factor-beta and interleukin-10 and exert their regulatory functions in a Th1/Th2-unrestricted fashion. |
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