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Stress-induced peptide release from rat intermediate pituitary
Authors:James A Carr  Linda C Saland  Ann Samora  Sima Desai  Salvador Benevidez
Institution:(1) Department of Anatomy, School of Medicine, University of New Mexico, 87131 Albuquerque, NM, USA
Abstract:Summary We tested the hypothesis that acute restraint stress results in ultrastructural evidence for enhanced release of alpha-melanocyte-stimulating hormone (agr-MSH) and beta-endorphin from the intermediate lobe (IL) of the rat pituitary. Measurements of plasma agr-MSH-and beta-endorphin-immunoreactivity (ir) were used to confirm ultrastructural findings. Plasma agr-MSH-ir was elevated after 20 and 30 min of restraint while plasma beta-endorphin-ir peaked 10 min after the onset of restraint. Ultrastructural analysis revealed a decrease in the content of secretory granules within IL cells of stressed rats. Analysis of Golgi-related immature secretory granules in IL cells indicated that new peptide synthesis was not enhanced after 30 min of restraint. These results confirm previous studies showing and elevation of plasma beta-endorphin and agr-MSH-ir during acute restraint. Furthermore, these results indicate that quantitative analysis at the ultrastructural level can be used to assess peptide release from IL secretory cells during stress.
Keywords:Pituitary gland  pars intermedia  Stress  Secretory granules  agr-MSH" target="_blank">gif" alt="agr" align="BASELINE" BORDER="0">-MSH  beta-Endorphin" target="_blank">gif" alt="beta" align="MIDDLE" BORDER="0">-Endorphin  Rat (Sprague-Dawley)
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