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Antiviral Activity of Some 2'-Deoxyuridine 5-Arylethynyl Derivatives |
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| Authors: | Andronova V. L. Skorobogatyi M. V. Manasova E. V. Berlin Yu. A. Korshun V. A. Galegov G. A. |
| Affiliation: | (1) Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, ul. Gamalei 16, Moscow, 123098, Russia;(2) Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, GSP, Moscow, 117997, Russia |
| Abstract: | 5-(3-Perylenylethynyl)-2'-deoxyuridine was prepared by crosslinking 5-iodo-2'-deoxyuridine derivatives with 3-ethynylperylene followed by deprotection. 5-(1-Perylenylethynyl)-, 5-(3-perylenylethynyl)-, and 5-[4-(2-benzoxazolyl)phenylethynyl]-2'-deoxyuridine were found to inhibit in Vero cells the replication of type 1 herpes simplex virus and its drug-resistant strains. |
| Keywords: | antiviral activity HSV-1 5-(3-perylenylethynyl)-2'-deoxyuridine 5-substituted 2'-deoxyuridines type 1 herpes simplex virus |
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