Oxytocin and its analogs, methyl-substituted in ortho-, meta- or para-position of aromatic ring of phenylalanine in position 2: NMR study and biological activities |
| |
Authors: | Budesínsky Milos Procházka Zdenko Slaninová Jirina |
| |
Affiliation: | Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague. |
| |
Abstract: | Complete analyses of NMR data of oxytocin (OT) and 4 analogues, ([o-MePhe(2)]OT, [mMe-Phe(2)]OT, [m-OMePhe(2)]OT and [p-MePhe(2)]OT), are given. The same conformational behavior in solution on one hand and large differences in biological activities on the other hand indicate that the compounds adopt a "biologically active conformation" at the stage of interaction with the receptor when the character of the substituent and its position on the aromatic ring may play a role in hindering attaining the ideal complementarity of both interacting components. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|