Model-specific selection of molecular targets for heart failure gene therapy |
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Authors: | Katz Michael G Fargnoli Anthony S Tomasulo Catherine E Pritchette Louella A Bridges Charles R |
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Institution: | Department of Surgery, Division of Cardiovascular Surgery, The University of Pennsylvania Medical Center, Philadelphia, PA, USA. |
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Abstract: | Heart failure (HF) is a complex multifaceted problem of abnormal ventricular function and structure. In recent years, new information has been accumulated allowing for a more detailed understanding of the cellular and molecular alterations that are the underpinnings of diverse causes of HF, including myocardial ischemia, pressure-overload, volume-overload or intrinsic cardiomyopathy. Modern pharmacological approaches to treat HF have had a significant impact on the course of the disease, although they do not reverse the underlying pathological state of the heart. Therefore gene-based therapy holds a great potential as a targeted treatment for cardiovascular diseases. Here, we survey the relative therapeutic efficacy of genetic modulation of β-adrenergic receptor signaling, Ca(2+) handling proteins and angiogenesis in the most common extrinsic models of HF. |
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Keywords: | angiogenesis animal models β‐adrenergic signaling Ca2+ handling proteins gene therapy heart failure |
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