The effects of betamethasone on plasma and intestinal calcium binding protein and on 25-hydroxyvitamin D3 metabolism in the pig |
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| Authors: | E M Maunder B A Sommerville A V Pillay R Ross D Marshall A D Care |
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| Affiliation: | 1. Department of Oncology, University College Hospital, London, UK;2. Cooperative Osteosarcoma Study Group (COSS), Klinikum Stuttgart - Olgahospital, Stuttgart, Germany;3. Stanford University Medical Center, Pediatric Hematology/Oncology, Palo Alto, USA;4. Division of Cancer, Surgery and Transplantation, and Scandinavian Sarcoma Group, Oslo University Hospital, Oslo;5. Institute for Clinical Medicine, University of Oslo, Oslo, Norway;6. Medical Research Council Clinical Trials Unit at University College London, London, UK;7. Children''s Oncology Group, Arcadia, USA;8. Department of Pediatrics and Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands;9. Center for Clinical Trials, University Hospital Münster, Münster, Germany;10. University of Helsinki and HUSLAB, Helsinki, Finland;11. University Hospital of Muenster, Muenster, Germany;12. Our Lady''s Children''s Hospital, Dublin, Ireland;13. Lucile Salter Packard Childrens Hospital Stanford, Palo Alto, USA;14. University Hospital Ghent, Gent, Belgium;15. Skane University Hospital, Lund University, Lund, Sweden;16. Royal National Orthopaedic Hospital, Stanmore;17. Cancer Institute, University College London, London, UK;18. Dana-Farber Cancer Institute, Boston;19. Section of Pediatric Hematology/Oncology, Montefiore Medical Center, Bronx, USA;20. Department of General Orthopedics and Tumor Orthopedics, University Hospital Muenster, Muenster, Germany;21. Royal Orthopaedic Hospital, Birmingham, UK;22. Department of Oncology, Oslo University Hospital, Norwegian Radium Hospital, Scandinavian Sarcoma Group, Oslo, Norway;23. Department of Pediatric Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;24. Bone Tumor Reference Center at the Institute of Pathology, University Hospital Basel, Basel, Switzerland;25. St Anna Children''s Hospital, Vienna, Austria;26. University Children''s Hospital Basel, Basel, Switzerland;27. Texas Children''s Cancer Centre, Baylor College of Medicine, Houston;28. H. Lee Moffit Cancer Centre & Research Institute, Tampa;29. Children''s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia;30. Memorial Sloan-Kettering Cancer Center, New York;31. Orthopedic Surgery, Johns Hopkins, Baltimore, USA;32. Department of Pediatric Hematology Oncology, University Hospital, Prague, Czech Republic;33. British Columbia Children''s Hospital, University of British Columbia, Vancouver, Canada;34. Cincinnati Children''s Hospital Medical Center, Cincinnati;35. Primary Children''s Hospital and Huntsman Cancer Institute, University of Utah, Salt Lake City;36. Mayo Clinic, Rochester, USA;37. Department of Radiation Oncology, Medical Center Hamburg-Eppendorf, Hamburg, Germany;38. Department of Pathology, Boston Children''s Hospital, Boston, USA;39. IWK Health Center, Dalhousie University, Halifax, Canada;1. Faculty of Economics and Business, Center for Fintech and Banking, & GRISKA, Universitas Sebelas Maret, Surakarta, Indonesia;2. INCEIF University, Kuala Lumpur, Malaysia;1. Cardiology Service, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México;2. Internal Medicine Department, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México;3. Endocrinology Service, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México;4. Echocardiography Laboratory, Cardiology Service, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México |
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| Abstract: | Betamethasone (50 micrograms/kg body weight/day) given to young pigs reduced calcium absorption, growth and plasma vitamin D dependent calcium binding protein (CaBP) concentration. No changes occurred in plasma 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and intestinal CaBP concentrations. 1,25(OH)2D3 (0.1 microgram/kg body weight/day) given with betamethasone increased calcium absorption although growth and plasma CaBP concentrations remained low. Intestinal CaBP levels remained unchanged. Plasma CaBP concentrations were not consistently related to intestinal CaBP or calcium absorption in the presence of betamethasone. We conclude that betamethasone-induced depression of calcium absorption was not mediated by alterations in intestinal CaBP, but the mechanism remains obscure. |
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