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Regulation of IgM expression by adjuvant activated splenic suppressor T cells |
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| Authors: | I Lowy L Leclercq J Theze |
| Institution: | 1. Immunology Department, Universitary Hospital Germans Trias i Pujol, Badalona, Spain;2. Transplant and Autoimmunity Group, Research Institute-IDIVAL, Santander, Spain;3. Universitary Hospital Marqués de Valdecilla-IDIVAL, Santander, Spain;4. Molecular Biology Department, University of Cantabria, Santander, Spain |
| Abstract: | Adjuvant-activated Lyt-2 positive suppressor T cells (Ts) are able to inhibit the expression of IgM plaque-forming cells (PFC) during a primary in vitro response to sheep red blood cells. Under the same experimental conditions these suppressor T cells do not affect a secondary IgM PFC response against SRBC. Activated Ts cells were also found to suppress the spontaneous IgM secretion of cultured B cells as well as the IgM production of B cells stimulated by lipopolysaccharide or by supernatant from a T-helper-cell clone. |
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