| 8-OHdG在医学领域的应用与研究进展 |
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| 引用本文： | 朴恩谊,徐立红. 8-OHdG在医学领域的应用与研究进展[J]. 中国细胞生物学学报, 2012, 0(5): 96-102 |
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| 作者姓名： | 朴恩谊 徐立红 |
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| 作者单位： | 浙江大学医学院生物化学与遗传学系 |
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| 基金项目： | 国家自然科学基金(No.20777067)资助项目~~ |
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| 摘 要： | 氧化应激带来的氧化损伤是造成人体多种损伤和病变的重要因素。8-羟基脱氧鸟苷(8-hydroxy-2’-deoxyguanosine,8-OHdG)作为DNA氧化损伤产物是广泛用于研究疾病中氧化损伤机制的关键标志物。国内外大量研究已普遍应用8-OHdG作为分析指标,该文着眼于近年来研究动向,就8-OHdG的作用机理与检测方法,以及职业与环境暴露的危害评价、辅助疾病早期诊断、治疗和新药研发等方面的应用作一综述。
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| 关 键 词： | 氧化应激 氧化损伤 8-OHdG |
Medical Application and Research Progress of 8-OHdG |
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| Piao Enyi,Xu Lihong. Medical Application and Research Progress of 8-OHdG[J]. , 2012, 0(5): 96-102 |
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| Authors: | Piao Enyi Xu Lihong |
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| Affiliation: | (Department of Biochemistry and Genetics,School of Medicine,Zhejiang University,Hangzhou 310058,China) |
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| Abstract: | Oxidative damages caused by oxidative stress are key factors for a variety of human injuries and diseases.8-hydroxy-deoxyguanosine(8-OHdG),a product of oxidative DNA damage,is widely applied in studying the mechanisms of oxidative damage in various diseases.A large number of studies have used 8-OHdG as an analytical indicator.The present paper reviews the recent development of 8-OHdG focusing on its effect mechanisms,detection methods as well as its application in hazard assessment of occupational and environmental exposure,in early diagnosis of disease,and in development of new drugs. |
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| Keywords: | oxidative stress oxidative damage 8-OHdG |
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