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Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways
Authors:Anna Koskinen  Sami Juslin  Riina Nieminen  Teemu Moilanen  Katriina Vuolteenaho  Eeva Moilanen
Affiliation:(1) The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Medisiinarinkatu 3, Tampere, FI-33014, Finland;(2) Coxa Hospital for Joint Replacement, Biokatu 6b, Tampere, FI-33520, Finland
Abstract:

Introduction  

Adiponectin is an adipokine that regulates energy metabolism and insulin sensitivity, but recent studies have pointed also to a role in inflammation and arthritis. The purpose of the present study was to investigate the association and effects of adiponectin on inflammation and cartilage destruction in osteoarthritis (OA).
Keywords:
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